The Clinical Pharmacology of Intranasal l-Methamphetamine
Author Information
Author(s): Mendelson John E, McGlothlin Dana, Harris Debra S, Foster Elyse, Everhart Tom, Jacob Peyton III, Jones Reese T
Primary Institution: Addiction Pharmacology Research Laboratory, The California Pacific Medical Center Research Institute
Hypothesis
What are the pharmacological effects of l-methamphetamine when used as a nasal decongestant?
Conclusion
Inhaled l-methamphetamine delivered from a non-prescription product produced minimal effects but may be a cardiodepressant.
Supporting Evidence
- Plasma l-methamphetamine levels were often below the level of quantification.
- Physiological changes were minimal and not dose-dependent.
- Small decreases in stroke volume and cardiac output suggesting mild cardiodepression were seen.
Takeaway
This study looked at how a nasal spray containing l-methamphetamine affects the heart and body, and found it doesn't do much, even at higher doses.
Methodology
Twelve subjects self-administered l-methamphetamine from a nonprescription inhaler at various doses, and physiological, cardiovascular, pharmacokinetic, and subjective effects were measured.
Potential Biases
Normotensive subjects may not represent the effects in hypertensive individuals.
Limitations
The lack of a placebo limits the ability to assess the importance of the small increases in blood pressure seen.
Participant Demographics
Twelve normotensive subjects aged 28 to 51 years.
Statistical Information
P-Value
p = 0.02
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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