CD37 Protein and Its Role in IgA Responses and Fungal Immunity
Author Information
Author(s): Annemiek B. van Spriel, Mariam Sofi, Kate H. Gartlan, Alie van der Schaaf, Ineke Verschueren, Ruurd Torensma, Reinier A. P. Raymakers, Bruce E. Loveland, Mihai G. Netea, Gosse J. Adema, Mark D. Wright, Carl G. Figdor
Primary Institution: University Medical Centre, Nijmegen, The Netherlands
Hypothesis
The tetraspanin protein CD37 inhibits IgA immune responses and regulates anti-fungal immunity.
Conclusion
CD37 inhibits IgA responses and enhances protection against fungal infections.
Supporting Evidence
- CD37-deficient mice showed a 15-fold increase in serum IgA levels.
- Neutralizing IL-6 reversed the increased IgA response in CD37-deficient mice.
- CD37-deficient mice were better protected from Candida albicans infection than wild-type mice.
Takeaway
CD37 is a protein that helps control how much IgA, an important antibody, is made. When this protein is missing, the body makes a lot more IgA and can fight off fungal infections better.
Methodology
The study involved experiments with CD37-deficient mice to assess IgA production and immune responses to Candida albicans.
Participant Demographics
Mice used in the study were CD37-deficient and wild-type strains.
Statistical Information
P-Value
p<0.0002
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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