Common Short Sense-Antisense Pairing in Human mRNAs
Author Information
Author(s): Wang Ping, Yin Shanye, Zhang Zhenguo, Xin Dedong, Hu Landian, Kong Xiangyin, Hurst Laurence D
Primary Institution: Institute of Health Sciences, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) and Shanghai Jiao Tong University School of Medicine (SJTUSM)
Hypothesis
Is it possible that coding RNA might regulate other coding RNA by short perfect sense-antisense binding?
Conclusion
The study suggests that short perfect sense-antisense pairing between transcripts of protein coding genes is a common occurrence.
Supporting Evidence
- All 24,968 mRNAs can form short pairs with at least one other mRNA.
- The density of pair sites in 5'-UTRs is markedly higher than that in CDS and 3'-UTRs.
- Transcripts with more potential partners have lower expression levels.
Takeaway
This study found that many human mRNAs can pair with each other in a special way that might help control how genes work.
Methodology
The study used computational methods to analyze 24,968 human protein coding mRNA sequences for potential short sense-antisense pairs.
Statistical Information
P-Value
P << 0.01
Statistical Significance
p < 0.01
Digital Object Identifier (DOI)
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