Evolution of the bgl Operon in E. coli
Author Information
Author(s): Sankar T. Sabari, Neelakanta Girish, Sangal Vartul, Plum Georg, Achtman Mark, Schnetz Karin
Primary Institution: Institute for Genetics, University of Cologne
Hypothesis
How has the bgl operon evolved in different phylogenetic groups of E. coli?
Conclusion
The bgl operon is maintained functionally in strains of the phylogenetic group B2, while it is eroded in groups A and B1, and absent in group D.
Supporting Evidence
- The bgl operon is present in strains of phylogenetic groups A, B1, and B2.
- 20% of strains in groups A and B1 have mutations in the bgl operon.
- bgl is functional in almost all B2 isolates.
Takeaway
This study looks at a part of E. coli's DNA that helps it use certain sugars. Some E. coli can still use this part, while others have lost it over time.
Methodology
The study involved typing the bgl operon in 174 strains of E. coli and analyzing their phenotypes and phylogenetic relationships.
Potential Biases
Potential bias in strain selection and environmental conditions during analysis.
Limitations
The study may not account for all environmental factors affecting bgl operon expression.
Participant Demographics
The study included 171 E. coli isolates and 3 strains of Escherichia albertii.
Statistical Information
P-Value
0.00026
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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