Blood flow modification by nicotinamide and metoclopramide in mouse tumours growing in different sites
1993
Effects of Nicotinamide and Metoclopramide on Blood Flow in Mouse Tumors
Sample size: 15
publication
Evidence: moderate
Author Information
Author(s): D.G. Hirst, B. Joiner, V.K. Hirst
Primary Institution: CRC Gray Laboratory
Hypothesis
How do nicotinamide and metoclopramide affect blood flow to mouse tumors in different sites?
Conclusion
Nicotinamide and metoclopramide can enhance blood flow to tumors, potentially improving drug delivery.
Supporting Evidence
- Nicotinamide increased cardiac output distribution to tumors by 17-92%.
- Metoclopramide consistently increased blood flow to muscle tumors.
- Nicotinamide's effects on blood flow were more reliable than those of metoclopramide.
Takeaway
Nicotinamide and metoclopramide help more blood reach tumors, which might make cancer treatments work better.
Methodology
The study used 86Rb uptake to measure cardiac output distribution to tumors in different sites after drug administration.
Limitations
The study did not analyze microregional blood flow heterogeneity in detail.
Participant Demographics
Male CBA mice, 12-16 weeks old, weighing 28-32 g.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
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