Recombinant Rabies Virus Prevents Rabies Development in Mice
Author Information
Author(s): Wang Hualei, Zhang Guoqing, Wen Yongjun, Yang Songtao, Xia Xianzhu, Fu Zhen F.
Primary Institution: University of Georgia
Hypothesis
Can recombinant rabies virus expressing GM-CSF prevent the development of rabies in mice after infection with street virus?
Conclusion
Intracerebral administration of recombinant rabies virus expressing GM-CSF significantly protects mice from developing rabies after infection.
Supporting Evidence
- 80% of mice treated with medium developed rabies, while none treated with LBNSE-GM-CSF at 2 dpi showed symptoms.
- 70% of mice survived when treated with LBNSE-GM-CSF at 4 dpi.
- 60% of mice survived when treated at 5 dpi, indicating significant protection compared to sham treatment.
Takeaway
Researchers found that a special rabies vaccine can help mice not get sick from rabies even after they were infected.
Methodology
Mice were infected with rabies virus and treated with recombinant virus expressing GM-CSF at various times post-infection, then monitored for survival and immune response.
Limitations
The study was conducted in mice, which may not fully represent human responses.
Participant Demographics
ICR mice aged 4-6 weeks were used in the study.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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