Chemokines Secreted by Monocytes After OK-432 Stimulation
Author Information
Author(s): Olsnes Carla, Stavang Helen, Brokstad Karl, Olofsson Jan, Aarstad Hans J
Primary Institution: University of Bergen
Hypothesis
How do mononuclear phagocytes respond to OK-432 stimulation in terms of chemokine secretion?
Conclusion
OK-432 stimulates monocytes to produce MCP-1 and MIP-1α/β, with CD36 modulating the response.
Supporting Evidence
- OK-432 stimulated MNPs to secrete MCP-1 and MIP-1α/β in healthy individuals and HNSCC patients.
- Chemokine secretion was significantly reduced under low-attachment conditions.
- CD36 and CD18 may mediate the chemokine response to OK-432.
Takeaway
When certain immune cells are exposed to a substance called OK-432, they release special signals that help fight infections and cancer.
Methodology
The study involved in vitro stimulation of monocytes with OK-432 and measurement of chemokine secretion using ELISA and Multiplex assays.
Limitations
The study primarily focused on in vitro conditions, which may not fully replicate in vivo responses.
Participant Demographics
The study included healthy individuals and patients with head and neck squamous cell carcinoma.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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