CCR5: A Key Target in HIV Infection and Treatment
Author Information
Author(s): Lopalco Lucia
Primary Institution: San Raffaele Scientific Institute
Hypothesis
Can targeting the CCR5 coreceptor provide a new strategy for preventing or limiting HIV infection?
Conclusion
The study suggests that CCR5 is a promising target for HIV prevention and therapy, with potential strategies including vaccination and antibody development.
Supporting Evidence
- CCR5 is a major co-receptor for HIV, facilitating its entry into host cells.
- Natural mutations in CCR5 can confer resistance to HIV infection.
- Anti-CCR5 antibodies have been found in individuals who control HIV infection.
Takeaway
CCR5 is like a door that HIV uses to enter cells, and scientists are exploring ways to block this door to stop the virus.
Methodology
The review discusses various studies on CCR5's role in HIV infection and the immune response, including genetic studies and clinical trials.
Limitations
The review is based on existing literature and may not cover all recent developments in CCR5 research.
Participant Demographics
The study references various populations, including HIV-exposed seronegative individuals and long-term non-progressors.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website