The Role of Interleukin-6 in Lung Inflammation and Pulmonary Hypertension in Mice
Author Information
Author(s): Savale Laurent, Tu Ly, Rideau Dominique, Izziki Mohamed, Maitre Bernard, Adnot Serge, Eddahibi Saadia
Primary Institution: INSERM U841, Université Paris XII, Créteil, France
Hypothesis
Does endogenous IL-6 contribute to hypoxia-induced pulmonary hypertension and lung inflammation?
Conclusion
IL-6 deficiency reduces the severity of hypoxia-induced pulmonary hypertension and lung inflammation in mice.
Supporting Evidence
- IL-6-/- mice showed decreased right ventricular systolic pressure compared to wild-type mice after hypoxia.
- Hypoxia increased IL-6 mRNA and protein levels in wild-type mice.
- IL-6-/- mice had less inflammatory cell recruitment in the lungs compared to wild-type mice.
Takeaway
This study found that mice without a protein called IL-6 had less lung inflammation and lower blood pressure in their lungs when exposed to low oxygen levels.
Methodology
The study used IL-6-deficient and wild-type mice exposed to hypoxia for 2 weeks to assess pulmonary hypertension and inflammation.
Limitations
The study's findings may not fully represent human pulmonary hypertension as IL-6 levels were not sustained in the mouse model.
Participant Demographics
Male mice aged 8–10 weeks were used in the study.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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