Severe morbidity and mortality in untreated HIV-infected children in a paediatric care programme in Abidjan, Côte d'Ivoire, 2004-2009

2011

Severe Health Issues in Untreated HIV-Infected Children in Côte d'Ivoire

Sample size: 405 publication 10 minutes Evidence: moderate

Author Information

Author(s): Desmonde Sophie, Coffie Patrick, Aka Edmond, Amani-Bosse Clarisse, Messou Eugène, Dabis François, Alioum Ahmadou, Ciaranello Andrea, Leroy Valériane

Primary Institution: Inserm, U897 & Institut de Santé Publique, Epidémiologie et Développement (ISPED), Université Victor Segalen Bordeaux 2, Bordeaux, France

Hypothesis

What is the clinical evolution of untreated HIV-infected children in a pediatric care program in Côte d'Ivoire?

Conclusion

Early access to care reduces the risk of severe morbidity in HIV-infected children, but untreated children still face high risks of severe morbidity and mortality.

Supporting Evidence

The risk of severe morbidity was 14% at 18 months.
Cumulative mortality reached 5.5% at 18 months.
Immunodeficiency was associated with a higher risk of mortality.

Takeaway

Kids with HIV who don't get treatment can get really sick or even die, but getting help early can make things better.

Methodology

Retrospective study of HIV-infected children enrolled in a care program from 2004-2009, assessing morbidity and mortality using cumulative incidence functions.