Review of Naratriptan for Migraine Treatment
Author Information
Author(s): Tfelt-Hansen Peer Carsten
Primary Institution: Department of Neurology, Danish Headache Center, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark
Hypothesis
Is naratriptan effective for treating migraines compared to placebo and other medications?
Conclusion
Naratriptan 2.5 mg is effective for acute migraine treatment and has a tolerability profile similar to placebo.
Supporting Evidence
- Naratriptan 2.5 mg was superior to placebo in 6 RCTs.
- Naratriptan 1 mg b.i.d. showed some effect in short-term prophylaxis for menstruation-associated migraine.
- Naratriptan 2.5 mg had a similar adverse effect profile to placebo.
Takeaway
Naratriptan helps people with migraines feel better, and it's as safe as taking a sugar pill.
Methodology
The review analyzed data from 17 double-blind, randomized, controlled trials found in the GSK Trial Register.
Potential Biases
The pharmaceutical company may have influenced the publication of results.
Limitations
Less than half of the trials were fully published, leading to potential publication bias.
Participant Demographics
The trials included a total of 6,112 patients, with varying demographics across multiple centers.
Statistical Information
P-Value
0.011
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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