Study of PEDF Gene Variants in Age-Related Macular Degeneration
Author Information
Author(s): Mattes Dietmar, Haas Anton, Renner Wilfried, Steinbrugger Iris, El-Shabrawi Yosuf, Wedrich Andreas, Werner Christoph, Schmut Otto, Weger Martin
Primary Institution: Medical University of Graz, Austria
Hypothesis
Is there an association between PEDF gene polymorphisms and exudative age-related macular degeneration in a white European population?
Conclusion
The study suggests that none of the investigated PEDF polymorphisms is likely a major risk factor for exudative AMD in a white European population.
Supporting Evidence
- The homozygous PEDF 72 Met/Met genotype was not significantly more prevalent in AMD patients compared to controls.
- The two promoter polymorphisms were in complete association.
- Haplotype frequencies were similar between AMD patients and control subjects.
Takeaway
The researchers looked at certain gene changes to see if they cause eye problems in older people, but they found that these changes don't seem to be a big problem for people in Europe.
Methodology
Case-control study with 269 patients with exudative AMD and 155 control subjects, using 5'-exonuclease assays for genotype determination.
Limitations
The study may not account for all genetic variations affecting AMD risk and was limited to a specific population.
Participant Demographics
Patients were of European origin, with a mean age of 78.4 years, and included 66.2% females.
Statistical Information
P-Value
p=0.99
Confidence Interval
95% CI: 0.67–1.49
Statistical Significance
p>0.05
Want to read the original?
Access the complete publication on the publisher's website