HCV Animal Models: A Journey of More than 30 Years
Author Information
Author(s): Philip Meuleman, Geert Leroux-Roels
Primary Institution: Center for Vaccinology, Ghent University and Hospital
Conclusion
The chimeric uPA-SCID mouse model is a useful surrogate for studying hepatitis C virus (HCV) infection and therapy.
Supporting Evidence
- The chimpanzee has been crucial for understanding HCV but is now limited due to ethical concerns.
- Chimeric uPA-SCID mice can be repopulated with human hepatocytes, making them susceptible to HCV infection.
- These mice allow for the study of HCV entry, replication, and the evaluation of antiviral compounds.
Takeaway
Scientists have been studying hepatitis C virus in animals for over 30 years, and now they have a special mouse model that helps them understand the virus better and test new treatments.
Methodology
The review discusses various animal models used to study HCV, including chimpanzees, transgenic mice, and chimeric uPA-SCID mice.
Limitations
The surgical procedure to transplant human hepatocytes into mice is challenging, and the quality of transplanted cells is crucial for successful infection.
Digital Object Identifier (DOI)
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