Calcitonin gene-related peptide stimulates proliferation of alveolar epithelial cells
2009
CGRP Stimulates Growth of Lung Cells
Sample size: 5
publication
Evidence: moderate
Author Information
Author(s): Kawanami Yukiko, Morimoto Yasuo, Kim Heungnam, Nakamura Takehiro, Machida Kazuhiko, Kido Takashi, Asonuma Etsuko, Yatera Kazuhiro, Yoshii Chiharu, Kido Masamitsu
Primary Institution: University of Occupational and Environmental Health, Japan
Hypothesis
CGRP proliferates alveolar epithelial cells.
Conclusion
CGRP stimulates proliferation of human alveolar epithelial cells in vivo and in vitro.
Supporting Evidence
- CGRP increased the proliferation of A549 cells in a dose and time dependent manner.
- CGRP8-37 decreased CGRP induced proliferation of DNA synthesis.
- Phosphorylation of ERK pathway was observed within 15 minutes and peaked in one hour.
- Histological examination indicated proliferation of alveolar epithelial cells in the rhCGRP-treated group.
Takeaway
CGRP helps lung cells grow, which could be important for healing lung injuries.
Methodology
In vitro and in vivo studies were conducted using A549 cells and male Wister rats to assess the effects of CGRP on cell proliferation.
Participant Demographics
Male Wister rats, 10 weeks old.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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