The G protein-coupled receptor subset of the dog genome is more similar to that in humans than rodents
2009
Dog GPCRs are more similar to human than rodent GPCRs
publication
Evidence: high
Author Information
Author(s): Haitina Tatjana, Fredriksson Robert, Foord Steven M, Schiöth Helgi B, Gloriam David E
Primary Institution: Uppsala University
Hypothesis
The G protein-coupled receptor (GPCR) repertoire in dogs is more similar to that in humans than in rodents.
Conclusion
The study found that the repertoire of dog non-olfactory GPCRs is more similar to that in humans compared to rodents.
Supporting Evidence
- The study identified 353 full-length GPCR gene sequences in the dog genome.
- There are 12 dog GPCR genes missing in humans and 24 human GPCR genes not found in dogs.
- The average protein sequence identity between dog and human GPCR orthologs is 86%.
Takeaway
Dogs have a lot of similar genes to humans that help them respond to drugs, more so than mice or rats do.
Methodology
The study involved searching the dog genome for non-olfactory GPCRs, manual curation of gene sequences, and phylogenetic analyses.
Limitations
Some genes may be missing due to incompleteness of the genome assembly.
Digital Object Identifier (DOI)
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