Antibody Levels Against Salmonella in Healthy People in Nepal
Author Information
Author(s): Bharat M Pokhrel, Rajendra Karmacharya, Shyam K Mishra, Janak Koirala
Primary Institution: Tribhuvan University, Institute of Medicine, Department of Microbiology
Hypothesis
What are the baseline antibody titers against Salmonella enterica in healthy individuals in Nepal?
Conclusion
The study suggests that the cutoff levels for diagnosing enteric fever in Nepal should be adjusted to higher antibody titers.
Supporting Evidence
- 62 out of 100 blood samples showed significant antibody titers against Salmonella.
- 15% of samples had anti-O titers of ≥ 1:80.
- 12% of samples had anti-H titers of ≥ 1:160 against Salmonella enterica serotype Typhi.
Takeaway
This study looked at healthy people in Nepal to see how many had antibodies against Salmonella. It found that many had higher levels than what doctors usually use to diagnose typhoid fever.
Methodology
Blood samples were collected from healthy individuals and tested for antibody titers against Salmonella enterica using the Widal test.
Potential Biases
Potential bias due to the exclusion of individuals with recent infections.
Limitations
The study had a small sample size and only included healthy individuals from a specific region.
Participant Demographics
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Digital Object Identifier (DOI)
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