Chemokine Gene Polymorphisms and Uveitis Outcomes
Author Information
Author(s): Ahad Muhammad A., Missotten Tom, Abdallah Atiyeh, Lympany Penny A., Lightman Susan
Primary Institution: Moorfields Eye Hospital, Imperial College, London, UK
Hypothesis
Can polymorphisms in chemokine genes predict visual outcomes in patients with immune-mediated posterior segment uveitis?
Conclusion
Polymorphisms in chemokine genes can influence the outcomes of patients with idiopathic immune-mediated posterior segment uveitis.
Supporting Evidence
- Patients with the G allele at MCP-1-2581 developed the disease at an earlier age.
- Patients with the A allele at RANTES-403 had better visual outcomes.
- Final visual acuity after 18 months was better in patients with the CCR5 32 bp deletion.
- Patients with the CCR2 64I allele had a higher risk of elevated intraocular pressure.
Takeaway
Some genes that help control inflammation can affect how well people with a certain eye disease do over time.
Methodology
A case-control study comparing 141 patients with uveitis to 282 matched controls, analyzing six polymorphisms using PCR.
Limitations
The utility for prediction of disease susceptibility of the studied polymorphisms is generally not robust and requires further analysis.
Participant Demographics
141 Caucasian patients with idiopathic immune-mediated posterior segment uveitis, mean age of onset 37.8 years, female to male ratio 1.4:1.
Statistical Information
P-Value
pc=0.003, pc=0.02, pc=0.04, pc=0.007
Confidence Interval
95% CI=0.18-0.88
Statistical Significance
p<0.05
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