Antibiotic Resistance in E. coli from Nigerian Students
Author Information
Author(s): Iruka N. Okeke, Susan T. Fayinka, Adebayo Lamikanra
Primary Institution: Obafemi Awolowo University
Hypothesis
What are the trends in antibiotic resistance prevalence in E. coli isolates from Nigerian students over a 13-year period?
Conclusion
The study found that antibiotic resistance in E. coli isolates from healthy Nigerian students increased significantly from 1986 to 1998.
Supporting Evidence
- The prevalence of resistance to chloramphenicol increased from 13.5% in 1986 to 59.8% in 1998.
- Isolates resistant to tetracycline increased from 34.9% to 100% over the study period.
- Resistance to multiple antibiotics increased from 30.2% in 1986 to 70.5% in 1998.
Takeaway
The study shows that many E. coli bacteria from Nigerian students are becoming resistant to antibiotics, which can make treating infections harder.
Methodology
Stool specimens were collected from students and tested for resistance to seven antimicrobial drugs using standard methods.
Potential Biases
Selection of resistance strains may have occurred before the volunteer hosts were colonized.
Limitations
No sampling was conducted in 1990 or 1992, and streptomycin resistance was not tested in 1994.
Participant Demographics
Participants were Nigerian students aged 16 to 32, with 45.8% being female.
Statistical Information
P-Value
p <0.05
Statistical Significance
p<0.05
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