Cell-to-Cell Spread of Retroviruses
2010
Cell-to-Cell Spread of Retroviruses
publication
10 minutes
Evidence: moderate
Author Information
Author(s): Sattentau Quentin J.
Primary Institution: The University of Oxford
Hypothesis
What is the mechanism of cell-to-cell transfer of HIV-1?
Conclusion
The study highlights the importance of virological synapses in the cell-to-cell spread of retroviruses like HIV-1.
Supporting Evidence
- Retroviruses spread by forming structures called virological synapses.
- HIV-1 can evade the immune system by spreading directly between cells.
- Cell-to-cell transfer of HIV-1 is more efficient than spreading through the bloodstream.
Takeaway
Viruses can jump from one cell to another without going into the space between them, which helps them spread faster and avoid being attacked by the immune system.
Methodology
The review summarizes recent advances in understanding the mechanisms of retroviral spread through virological synapses.
Limitations
The review does not provide new experimental data but summarizes existing literature.
Digital Object Identifier (DOI)
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