Cardiac Troponin I Levels in Female Dogs with Pyometra Before and After Surgery
Author Information
Author(s): Lena Pelander, Ragnvi Hagman, Jens Häggström
Primary Institution: Swedish University of Agricultural Sciences, Uppsala, Sweden
Hypothesis
Does the concentration of cardiac Troponin I indicate myocardial cell damage in dogs with pyometra before and after ovariohysterectomy?
Conclusion
Mild to moderate increases in cardiac Troponin I are common in dogs with pyometra before and after surgery, but their clinical significance is uncertain.
Supporting Evidence
- 80% of the dogs with pyometra fulfilled the criteria for systemic inflammatory response syndrome (SIRS).
- 28% of the dogs had increased cardiac Troponin I concentrations before surgery.
- 39% of the dogs had increased cardiac Troponin I concentrations the day after surgery.
Takeaway
This study looked at heart damage in sick dogs before and after surgery, finding that many had some heart damage, but it's not clear how serious it is.
Methodology
Serum cardiac Troponin I concentrations were measured preoperatively and one day after surgery in 46 female dogs with pyometra and 15 control dogs.
Potential Biases
Potential bias due to the influence of stress and excitement on clinical parameters used to diagnose SIRS.
Limitations
The study did not rule out underlying subclinical cardiac disease in the participating dogs.
Participant Demographics
46 female dogs with pyometra, median age 8.5 years, median weight 29 kg; 15 control female dogs, median age 5 years, median weight 27 kg.
Statistical Information
P-Value
0.016
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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