Electrospun PLLA Nanofiber Scaffolds and Their Use in Combination with BMP-2 for Reconstruction of Bone Defects
2011

Bone Repair with Electrospun PLLA/BMP-2 Nanofibers

Sample size: 120 publication Evidence: high

Author Information

Author(s): Schofer Markus D., Roessler Philip P., Schaefer Jan, Theisen Christina, Schlimme Sonja, Heverhagen Johannes T., Voelker Maximilian, Dersch Roland, Agarwal Seema, Fuchs-Winkelmann Susanne, Paletta Jürgen R. J.

Primary Institution: University Hospital Marburg, Germany

Hypothesis

Can electrospun PLLA nanofiber scaffolds combined with BMP-2 enhance bone regeneration in vivo?

Conclusion

PLLA nanofibers facilitate cell colonization and, when combined with BMP-2, significantly enhance bone regeneration.

Supporting Evidence

  • PLLA scaffolds showed good cell colonization but limited bone formation.
  • PLLA/BMP-2 scaffolds resulted in significantly better bone regeneration.
  • Bone density increased significantly in the PLLA/BMP-2 group compared to other treatments.

Takeaway

This study shows that special fibers can help heal broken bones faster, especially when a growth factor is added.

Methodology

The study used a rat model with critical size calvarial defects treated with different materials, including PLLA and PLLA/BMP-2 scaffolds, and evaluated bone regeneration through CT scans and histological analysis.

Limitations

The study was conducted in a non-weight-bearing model, which may not fully represent the conditions in weight-bearing bones.

Participant Demographics

Adult male Sprague-Dawley rats were used in the study.

Statistical Information

P-Value

p≤0.001

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1371/journal.pone.0025462

Want to read the original?

Access the complete publication on the publisher's website

View Original Publication