Potential prognostic marker ubiquitin carboxyl-terminal hydrolase-L1 does not predict patient survival in non-small cell lung carcinoma
2011

UCH-L1 and Lung Cancer: No Link to Patient Survival

Sample size: 140 publication Evidence: moderate

Author Information

Author(s): Katy S. Orr, Zhanzhong Shi, W. Mark Brown, Kathleen A. O'Hagan, Terence R. Lappin, Perry Maxwell, Melanie J. Percy

Primary Institution: Queen's University Belfast

Hypothesis

Does UCH-L1 serve as a prognostic marker for advanced stage non-small cell lung carcinoma?

Conclusion

UCH-L1 is involved in lung cancer cell processes but does not correlate with patient survival.

Supporting Evidence

  • UCH-L1 expression was decreased by siRNA in both cell lines.
  • Increased cell death was observed in H838 adenocarcinoma cells with reduced UCH-L1.
  • Metastatic potential was reduced in H157 cells with UCH-L1 knockdown.
  • Immunohistochemical staining confirmed UCH-L1 was preferentially expressed in squamous cell carcinoma.
  • Kaplan-Meier curves showed no correlation between UCH-L1 expression levels and patient outcome.

Takeaway

Researchers studied a protein called UCH-L1 in lung cancer cells and found it might help the cells survive and move, but it doesn't help predict how long patients will live.

Methodology

The study used NSCLC cell lines and patient tumor samples to analyze UCH-L1 expression and its effects on cell survival and migration.

Limitations

The study did not find a correlation between UCH-L1 expression and patient survival, suggesting other factors may influence prognosis.

Participant Demographics

140 NSCLC patients, including 85 squamous cell carcinomas and 55 adenocarcinomas.

Statistical Information

P-Value

<0.01

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1186/1756-9966-30-79

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