Impact of introducing multiple evidence-based clinical practice protocols in a medical intensive care unit: a retrospective cohort study

2007

Impact of Evidence-Based Protocols in ICU

Sample size: 8386 publication Evidence: moderate

Author Information

Author(s): Afessa Bekele, Gajic Ognjen, Keegan Mark T, Seferian Edward G, Hubmayr Rolf D, Peters Steve G

Primary Institution: Mayo Clinic College of Medicine

The study aims to determine the impact of introducing multiple evidence-based protocols on patient outcomes in a medical intensive care unit.

The introduction of multiple evidence-based protocols is associated with improved outcomes in critically ill medical patients.

The observed mortality rates decreased from 19.3% in the pre-protocol period to 16.9% during the protocol period.
The severity-adjusted risk of dying was significantly lower during the protocol period compared to the pre-protocol period.
The average 28-day ICU free days improved during the protocol period compared to the pre-protocol period.

Using specific treatment plans helped sick patients in the ICU get better and stay alive longer.

A retrospective cohort study analyzing data from 8,386 patients admitted to the MICU over a period from January 2000 to June 2005.

Potential confounding variables were not fully accounted for, and the retrospective design may introduce bias.

The study was conducted in a single medical center, which may limit the generalizability of the findings.

Of the 8,386 patients, 94.3% were white and 51.8% were male, with a mean age of 62.3 years.

0.0038

0.655 – 0.922

p<0.05

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