NFκB1 and NFκBIA Polymorphisms Linked to Colorectal Cancer Risk
Author Information
Author(s): Song Shunxin, Chen Dianke, Lu Jiachun, Liao Jiawei, Luo Yanxin, Yang Zuli, Fu Xinhui, Fan Xinjuan, Wei Yisheng, Yang Lei, Wang Lei, Wang Jianping
Primary Institution: Gastrointestinal Institute of Sun Yat-Sen University, The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People's Republic of China
Hypothesis
The NFκB1 (-94del/insATTG) and NFκBIA (2758 A>G) polymorphisms are associated with colorectal cancer (CRC) susceptibility.
Conclusion
NFκB1 and NFκBIA polymorphisms appear to jointly contribute to the risk of colorectal cancer in a southern Chinese population.
Supporting Evidence
- Both NFκB1-94 ins/delATTG and NFκBIA 2758 A>G polymorphisms were correlated with CRC risk.
- The combined genotypes with 2 variant alleles were associated with an increased risk of CRC.
- Significant trends for 2 variant alleles were more pronounced among subgroups of younger individuals and those with a family history of cancer.
Takeaway
Some people have genetic changes that make them more likely to get colon cancer. This study looked at those changes in people from southern China.
Methodology
A case-control study with 1001 CRC patients and 1005 controls, genotyping polymorphisms using PCR-RFLP and performing luciferase assays.
Potential Biases
Potential biases in self-reported data on lifestyle factors.
Limitations
The study is limited to a specific population and may not be generalizable to other ethnic groups.
Participant Demographics
Participants were genetically unrelated ethnic Han Chinese from Guangzhou, China.
Statistical Information
P-Value
p<0.01
Confidence Interval
95% CI = 1.14–1.86
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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