Metastin Expression in Pancreatic Cancer
Author Information
Author(s): Nagai Kazuyuki, Doi Ryuichiro, Katagiri Fumihiko, Ito Tatsuo, Kida Atsushi, Koizumi Masayuki, Masui Toshihiko, Kawaguchi Yoshiya, Tomita Kenji, Oishi Shinya, Fujii Nobutaka, Uemoto Shinji
Primary Institution: Kyoto University
Hypothesis
High levels of KiSS-1 and GPR54 expression could be associated with better survival of pancreatic cancer patients.
Conclusion
Strong expression of metastin and GPR54 by pancreatic cancer is associated with longer survival.
Supporting Evidence
- Tumors that were negative for both metastin and GPR54 expression were significantly larger than those positive for either.
- Recurrence was less frequent in patients with metastin-positive tumors compared to those with metastin-negative tumors.
- Strong expression of metastin and GPR54 was significantly correlated with longer survival.
- Metastin expression was an independent prognostic factor for longer survival.
Takeaway
This study found that a protein called metastin can help pancreatic cancer patients live longer. If tumors have more metastin, patients tend to do better.
Methodology
Immunohistochemical expression of metastin and GPR54 was evaluated in pancreatic cancer tissues from 53 patients, and plasma metastin levels were measured in 23 patients.
Limitations
The study had a limited sample size and follow-up period.
Participant Demographics
25 men (47.2%) and 28 women (52.8%) with a mean age of 65.6 years.
Statistical Information
P-Value
p = 0.02
Confidence Interval
95% confidence interval, 1.1–4.7
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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