Impact of Viral Hepatitis on Liver Cancer Surgery Outcomes
Author Information
Author(s): Zhou Yanming, Si Xiaoying, Wu Lupeng, Su Xu, Li Bin, Zhang Zhiming
Primary Institution: The First affiliated Hospital of Xiamen University, Xiamen, China
Hypothesis
Does the viral hepatitis status affect the prognosis of patients undergoing hepatic resection for hepatocellular carcinoma?
Conclusion
Patients with hepatitis B or C have a poorer prognosis after liver surgery compared to those without these infections.
Supporting Evidence
- Patients with HBV or HCV infection had a worse 5-year disease-free survival compared to those without.
- 5-year overall survival rates were not significantly different between HBV and HCV groups.
- Patients with negative serology had a tendency for better survival outcomes.
Takeaway
If you have liver cancer and also have hepatitis B or C, your chances of doing well after surgery are not as good as someone who doesn't have those viruses.
Methodology
A meta-analysis of 20 studies comparing postoperative survival rates among patients with different viral hepatitis statuses.
Potential Biases
Potential biases from observational study designs and selection criteria.
Limitations
The studies included varied in quality and surgical practices, and most were conducted in Asian populations, limiting generalizability.
Participant Demographics
The study included 4744 patients, with a significant number being male and varying ages across different hepatitis groups.
Statistical Information
P-Value
<0.001
Confidence Interval
95% CI: 0.28 to 0.53
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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