BIOLOGICAL AGING PATHWAYS THAT UNDERLIE LIFE COURSE SOCIOECONOMIC DISPARITIES IN PHYSICAL FUNCTION AND LONGEVITY
2024
Biological Aging Pathways and Socioeconomic Disparities
Sample size: 1295
publication
Evidence: moderate
Author Information
Author(s): Tara Gruenewald, Naomi Podber
Primary Institution: Chapman University
Hypothesis
Does a DNA methylation profile and physiological dysregulation mediate the effects of socioeconomic disadvantage on physical function and survival?
Conclusion
The study found that biological aging pathways contribute to socioeconomic disparities in physical function and longevity.
Supporting Evidence
- Greater socioeconomic disadvantage was linked to increased mortality hazard.
- Higher gait speed and chair stand time were associated with greater socioeconomic disadvantage.
- Greater DunedinPACE and allostatic load were linked to slower physical function and lower survival.
Takeaway
People who have had a harder life can age faster, which makes them less able to move and live longer.
Methodology
The study used data from the Midlife in the U.S. Study, measuring socioeconomic indicators, biological aging, and physical function.
Participant Demographics
Participants were aged 26–86, with 55.4% female and 69.0% white.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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