WU Polyomavirus: A Recently Detected Virus Causing Respiratory Disease?
Author Information
Author(s): Kleines Michael, Häusler Martin, Krüttgen Alexander, Scheithauer Simone
Primary Institution: University Hospital Aachen, RWTH Aachen
Hypothesis
Is WU polyomavirus (WUPyV) a causative agent of respiratory disease?
Conclusion
The available data do not prove WUPyV to be a human pathogen, and further investigations are necessary.
Supporting Evidence
- WUPyV was detected in 0.4% to 11.5% of respiratory tract specimens from children with respiratory disease.
- Co-infection rates with established respiratory viruses ranged from 30.8% to 91.7%.
- Detection of WUPyV in stool and serum suggests systemic infections.
Takeaway
Scientists found a new virus called WU polyomavirus in kids with breathing problems, but they aren't sure if it really makes people sick.
Methodology
The virus was discovered through shotgun sequencing of respiratory tract specimens.
Potential Biases
The studies may be biased due to the inclusion of only symptomatic patients.
Limitations
Most studies are retrospective and do not include asymptomatic control groups.
Participant Demographics
Infections were predominantly detected in children under 3 years of age.
Digital Object Identifier (DOI)
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