Loss of full length CtBP1 expression enhances the invasive potential of human melanoma
2009
CtBP1 Loss Increases Melanoma Cell Invasiveness
publication
Evidence: moderate
Author Information
Author(s): Winklmeier Andreas, Poser Ina, Hoek Keith S, Bosserhoff Anja K
Primary Institution: Institute of Pathology, University Regensburg
Hypothesis
CtBP1 acts as a tumor suppressor by negatively regulating genes involved in melanoma development and progression.
Conclusion
This study revealed that reduction of CtBP1 expression is correlated with the migratory and invasive potential of melanoma cells.
Supporting Evidence
- CtBP1 expression is lost in melanoma cells.
- Reduction of CtBP1 leads to increased expression of melanoma inhibitory activity (MIA).
- CtBP1 regulates genes associated with tumor metastasis.
Takeaway
When a protein called CtBP1 is reduced in melanoma cells, these cells become better at moving and invading other tissues.
Methodology
The study used PCR, Boyden Chamber assays, and gene expression analysis to evaluate the role of CtBP1 in melanoma.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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