Protein kinase Cε: an oncogene and emerging tumor biomarker
2009
Protein kinase Cε: an oncogene and emerging tumor biomarker
publication
Evidence: high
Author Information
Author(s): Gorin Michael A, Pan Quintin
Primary Institution: University of Miami, Miller School of Medicine
Hypothesis
PKCε plays a crucial role in oncogenesis and may serve as a tumor biomarker.
Conclusion
PKCε is frequently overexpressed in various cancers and is associated with aggressive disease and poor prognosis.
Supporting Evidence
- PKCε is overexpressed in tumor-derived cell lines and histopathological tumor specimens from various organ sites.
- Overexpression of PKCε has been shown to increase proliferation, motility, and invasion of cancer cells.
- PKCε has been implicated in promoting an aggressive metastatic phenotype in multiple cancer types.
Takeaway
PKCε is a protein that can help cancer cells grow and spread, and scientists think it could be a useful marker for cancer.
Methodology
The review summarizes existing literature on PKCε's role in cancer biology, including its effects on cell proliferation, motility, and invasion.
Limitations
The review does not provide new experimental data but synthesizes existing findings.
Digital Object Identifier (DOI)
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