Cognitive Performance in Multiple Sclerosis: A Study Using a Computerized Test
Author Information
Author(s): Edgar Chris, Jongen Peter J, Sanders Evert, Sindic Christian, Goffette Sophie, Dupuis Michel, Jacquerye Philippe, Guillaume Daniel, Reznik Regine, Wesnes Keith
Primary Institution: United BioSource Corporation
Hypothesis
Can a brief computerized cognitive battery effectively assess cognitive performance in patients with relapsing remitting multiple sclerosis?
Conclusion
The study found that the Cognitive Drug Research System is a valid tool for assessing cognitive performance in patients with relapsing remitting multiple sclerosis.
Supporting Evidence
- The CDR battery showed good test-retest reliability for most cognitive measures.
- Cognitive impairment was associated with greater disability scores on the EDSS.
- The study identified significant impairments in attention and information processing speed.
Takeaway
This study looked at how well a computer test can check how well people with multiple sclerosis think and remember things. It found that the test works pretty well.
Methodology
Patients were assessed using the Cognitive Drug Research battery and compared with other cognitive measures over time.
Potential Biases
Potential bias due to the lack of randomization in patient selection and the observational nature of the study.
Limitations
The study was observational and lacked a control group, which limits the ability to draw conclusions about treatment effects.
Participant Demographics
43 patients, 30 female and 13 male, mean age 38.8 years.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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