Dietary Restriction Improves Kidney Health in Diabetic Rats
Author Information
Author(s): Munehiro Kitada, Ai Takeda, Takako Nagai, Hiroki Ito, Keizo Kanasaki, Daisuke Koya
Primary Institution: Kanazawa Medical University
Hypothesis
Does dietary restriction have protective effects against diabetic nephropathy in Wistar fatty rats?
Conclusion
Dietary restriction reduced inflammation and improved kidney function in diabetic rats by restoring Sirt1 levels.
Supporting Evidence
- Dietary restriction significantly reduced urinary albumin excretion in diabetic rats.
- Creatinine clearance was restored in rats undergoing dietary restriction.
- Inflammation markers in the kidneys were decreased after dietary restriction treatment.
- Sirt1 protein levels were restored in the kidneys of rats on a dietary restriction.
- Histological analysis showed reduced mesangial expansion and renal fibrosis in treated rats.
Takeaway
Eating less food can help sick rats with diabetes feel better and keep their kidneys healthy.
Methodology
Diabetic rats were given a 40% dietary restriction for 24 weeks, and various kidney functions and histological changes were assessed.
Potential Biases
Potential bias in the selection of animal models and the interpretation of histological data.
Limitations
The study was conducted on a specific rat model, which may not fully represent human diabetic nephropathy.
Participant Demographics
Male diabetic Wistar fatty rats (WFRs) and age-matched nondiabetic Wistar lean rats (WLRs).
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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