Multiple Primary Cancers in Switzerland
Author Information
Author(s): F. Levi, L. Randimbison, V.-C. Tel, I. Rolland-Portal, S. Franceschi, C. La Vecchia
Primary Institution: Registre vaudois des tumeurs, Institut universitaire de medecine sociale et preventive
Hypothesis
What is the incidence of second primary cancers following any specific neoplasm?
Conclusion
The overall excess risk of a second primary cancer is relatively limited, about 20%, and is at least partly due to increased surveillance.
Supporting Evidence
- Among 34,615 cases of incident neoplasms, there were 2,185 second primaries.
- Significantly elevated ratios were registered for cancers of the oral cavity and pharynx.
- After lung cancer, the overall SIR was 1.7 for males and 2.6 for females.
- Significantly elevated SIRs were observed for kidney following bladder cancer.
- Some associations can be related to common risk factor exposure, such as tobacco.
Takeaway
This study looked at how often people get a second cancer after having one, and found that it's not very common, but some types of cancers are more likely to lead to others.
Methodology
Data from the Vaud Cancer Registry was analyzed, including incident cases of malignant neoplasms from 1974 to 1989, with follow-up for second primary cancers.
Potential Biases
Potential issues with incomplete registration of second cancers, particularly non-melanoma skin cancers.
Limitations
The study population was relatively small and the follow-up period was limited, which may affect the number of multiple primary cancers examined.
Participant Demographics
The study included 34,615 cases of first diagnosed cancer primaries, with 18,001 males and 16,614 females.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
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