Combining Antigen Therapy with GABA Treatment to Help Diabetic Mice
Author Information
Author(s): Tian Jide Dang, Hoa Kaufman, Daniel L.
Primary Institution: Department of Molecular and Medical Pharmacology, University of California Los Angeles
Hypothesis
Can combining antigen-based therapy with GABA treatment prolong the survival of transplanted ß-cells in diabetic NOD mice?
Conclusion
The combination of GABA and antigen-based therapy significantly prolonged the survival of transplanted ß-cells in diabetic mice compared to monotherapies.
Supporting Evidence
- GABA treatment significantly prolonged the survival of transplanted ß-cells in diabetic NOD mice.
- Mice treated with GAD/alum and GABA remained normoglycemic for 10-11 weeks post-transplantation.
- Monotherapy with GABA or GAD/alum alone only prolonged normoglycemia for about 3 weeks.
Takeaway
Researchers found that giving a special treatment with GABA along with another therapy helped diabetic mice keep their new insulin-producing cells alive longer.
Methodology
Diabetic NOD mice were treated with GAD/alum and GABA, then received pancreas grafts and were monitored for hyperglycemia.
Limitations
The study was conducted in a mouse model, which may not fully translate to human conditions.
Participant Demographics
Female NOD mice were used in the study.
Statistical Information
P-Value
p<0.005
Statistical Significance
p<0.005
Digital Object Identifier (DOI)
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