Predictors of Rapid HIV Progression in Untreated Argentinean Seroconverters
Author Information
Author(s): Socías M Eugenia, Sued Omar, Laufer Natalia, Lázaro María E, Mingrone Horacio, Pryluka Daniel, Remondegui Carlos, Figueroa María I, Cesar Carina, Gun Ana, Turk Gabriela, Bouzas María B, Kavasery Ravi, Krolewiecki Alejandro, Pérez Héctor, Salomón Horacio, Cahn Pedro
Primary Institution: Grupo Argentino de Seroconversión Study Group
Hypothesis
Acute retroviral syndrome and high baseline viral load are predictors of rapid HIV progression among untreated Argentinean seroconverters.
Conclusion
In Argentina, primary HIV infection is associated with significant morbidity, and treatment should be considered for patients with acute retroviral syndrome and high baseline viral load to prevent disease progression.
Supporting Evidence
- 74% of subjects presented with acute retroviral syndrome.
- 26% of untreated patients progressed at 12 months compared to 7% in the treated group.
- Progression rate among untreated patients with ARS was 34% versus 13% in asymptomatic patients.
Takeaway
This study found that people in Argentina who get HIV and have certain symptoms or high viral loads are more likely to get sicker quickly, so doctors should think about starting treatment sooner.
Methodology
Cox regression was used to analyze predictors of progression at 12 months among untreated patients diagnosed with primary HIV infection.
Potential Biases
There may be bias in identifying patients, as only the most symptomatic individuals might have been tested for HIV.
Limitations
The study may have limited generalizability due to the overrepresentation of symptomatic patients and potential biases in HIV testing practices.
Participant Demographics
Most participants were male (81.3%), with a median age of 32 years, and 53% identified as men who have sex with men.
Statistical Information
P-Value
0.01
Confidence Interval
95% CI 22.5-46.3
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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