LIF Enhances Decidualization in Humans and Mice
Author Information
Author(s): Shuya Lorraine Lin, Menkhorst Ellen Melaleuca, Yap Joanne, Li Priscilla, Lane Natalie, Dimitriadis Evdokia
Primary Institution: Prince Henry's Institute, Clayton, Melbourne, Australia
Hypothesis
Does leukemia inhibitory factor (LIF) play a role in the decidualization of endometrial stromal cells in humans and mice?
Conclusion
LIF is an important regulator of decidualization in both humans and mice.
Supporting Evidence
- LIF enhanced the secretion of prolactin, indicating increased decidualization.
- LIF and its receptor were localized to decidual cells in both human and murine tissues.
- Blocking LIF action in mice reduced the area of decidualization.
- Exogenous LIF increased the secretion of cytokines IL6 and IL15 in decidualized human endometrial stromal cells.
Takeaway
LIF helps the cells in the uterus get ready for pregnancy by making them change into a special type of cell needed for a baby to grow.
Methodology
The study involved ex vivo and in vivo experiments to assess the effects of LIF on decidualization in human endometrial stromal cells and murine models.
Limitations
The study may not fully replicate the complex in vivo environment of human pregnancy.
Participant Demographics
Women with regular menstrual cycles and healthy first trimester decidual tissue.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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