Effect of Semaglutide on Physical Function and Aging in Older Adults
Author Information
Author(s): Cortes Tiffany, Robbins Ronna, Serra Monica, Espinoza Sara, Musi Nicolas, Barrus Hannah, Brown Kevin, Campos Annalis
Primary Institution: The University of Texas Health San Antonio
Hypothesis
This study will provide insight on the role of GLP1 receptor agonists in overweight and obese adults with prediabetes or diabetes on important clinical outcomes beyond glycemic control.
Conclusion
Semaglutide may improve physical function and muscle mass in older adults with prediabetes or diabetes.
Supporting Evidence
- Semaglutide typically results in average reductions in hemoglobin A1c of 1.5% and weight loss of 12%.
- Participants are randomized 1:1 to receive either semaglutide 1mg plus lifestyle counseling or lifestyle counseling only.
Takeaway
This study is looking at whether a diabetes medication can help older people feel stronger and healthier.
Methodology
A 20-week open label, randomized trial with older adults with prediabetes or diabetes and who are overweight or obese.
Participant Demographics
20 older adults, 50% women, average age 76.7 years, average BMI 32.9 kg/m2.
Digital Object Identifier (DOI)
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