ASSOCIATION BETWEEN POLYPHARMACY AND Α-KLOTHO IN US OLDER ADULTS: THE MEDIATION ROLE OF INFLAMMATORY MARKERS
2024
Polypharmacy and Aging Protein Levels in Older Adults
Sample size: 3569
publication
Evidence: moderate
Author Information
Author(s): Wei Kai, Chen Chun, Yang Yanping, Wang Libin, Sun Shuimei
Primary Institution: Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China
Hypothesis
Is there an association between polypharmacy and α-klotho levels in older adults?
Conclusion
Polypharmacy is linked to lower levels of α-klotho, potentially mediated by inflammation.
Supporting Evidence
- The polypharmacy group had 1,591 participants, representing 42.7% of the sample.
- The median α-klotho level in the polypharmacy group was significantly lower than in the non-polypharmacy group.
- Polypharmacy was negatively associated with α-klotho after adjusting for multiple variables.
- Mediation analysis showed that inflammatory biomarkers mediated the association between polypharmacy and α-klotho.
Takeaway
Taking many medications can lower a protein that helps with aging in older people, and inflammation might play a role in this.
Methodology
The study used weighted linear regression and mediation analysis on data from the National Health and Nutrition Examination Survey.
Participant Demographics
Participants were aged 65-79 years, with a mix of men and women.
Statistical Information
P-Value
p<0.01
Confidence Interval
95% CI -0.0855 to -0.0157
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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