Prognostic Factors in Osteosarcoma
Author Information
Author(s): Flemming Brandt Sorensen, Kenneth Jensen, Michael Vaeth, Henrik Hager, Anette Mariane Daa Funder, Akmal Safwat, Johnny Keller, Mariann Christensen
Primary Institution: Aarhus University Hospital
Hypothesis
To investigate angiogenesis, multiple drug resistance (MDR) and proliferative activity as prognostic variables in patients suffering from osteosarcoma.
Conclusion
The study found that estimates of angiogenesis, proliferation, p53, and Pgp expressions did not demonstrate sufficient power to serve as predictors of treatment response or survival in osteosarcoma patients.
Supporting Evidence
- Chemotherapy reduced the rate of amputations.
- The overall disease-specific survival was 47%, increasing to 54% in patients receiving pre-operative chemotherapy.
- Statistical analyses showed prognostic impact exclusively by patient age and type of osteosarcoma.
Takeaway
This study looked at how certain factors might predict how well patients with bone cancer do, but it found that these factors didn't really help in predicting outcomes.
Methodology
Histologic biopsies from 117 patients were immunohistologically investigated regarding angiogenesis, proliferative activity, and the expression of p53 and MDR.
Potential Biases
Possible bias due to patient selection and data confounding, especially related to treatment variables.
Limitations
The study's retrospective design may inflict data confounding and bias.
Participant Demographics
{"sex":{"women":41,"men":76},"age":{"mean":23.8,"sd":16.6,"range":"4-74"},"tumor_site":{"femur":66,"tibia":21,"pelvis":10,"humerus_and_radius":12,"fibula":6,"tarsal_bones":2}}
Statistical Information
P-Value
{"angiogenesis":null,"proliferation":null,"p53":null,"mdr":null}
Digital Object Identifier (DOI)
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