Maternal Antibodies and Hepatitis B Vaccine Response in Infants
Author Information
Author(s): Wang Zhiqun, Zhang Shu, Luo Chao, Wu Qianzhen, Liu Qilan, Zhou Yi-Hua, Hu Yali
Primary Institution: Nanjing Drum Tower Hospital, Nanjing University Medical School
Hypothesis
Does maternal antibody against hepatitis B surface antigen influence the long-term immunogenicity of the hepatitis B vaccine in infants?
Conclusion
Maternal anti-HBs in infants does not inhibit the long-term immunogenicity of the hepatitis B vaccine.
Supporting Evidence
- 84.1% of infants had higher anti-HBs concentrations than their mothers.
- The positive rate of anti-HBs in infants with maternal anti-HBs was comparable to those without.
- Maternal anti-HBs did not impair the long-term immune response to hepatitis B vaccination.
Takeaway
Moms can pass antibodies to their babies, but these don't stop the babies from getting the hepatitis B vaccine's benefits.
Methodology
The study involved 338 pairs of mothers and infants, comparing anti-HBs responses in infants with and without maternal anti-HBs.
Potential Biases
Potential selection bias due to the exclusion of mothers with chronic diseases.
Limitations
The follow-up period was relatively short and the dropout rate was high in the prospective cohort.
Participant Demographics
Mothers aged 20-36 years, with a mix of vaccinated and unvaccinated individuals.
Statistical Information
P-Value
0.688
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website