Gene Therapy with Helper-Dependent Adenoviral Vectors: Current Advances and Future Perspectives
Author Information
Author(s): Francesco Vetrini, Philip Ng
Primary Institution: Baylor College of Medicine, Houston, TX, USA
Conclusion
Helper-dependent adenoviral vectors (HDAds) show significant potential for long-term gene therapy applications with reduced immune responses compared to earlier adenoviral vectors.
Supporting Evidence
- HDAds can mediate high efficiency transduction without integrating into the host genome.
- These vectors have shown long-term expression of therapeutic genes with minimal toxicity.
- HDAds have been successfully used in various animal models for gene therapy applications.
Takeaway
This study talks about a new type of virus that can deliver genes to cells without causing a lot of harm, which could help treat diseases better.
Methodology
The review summarizes the biology and structure of HDAds, their applications in gene therapy, and discusses the challenges and advancements in their clinical use.
Limitations
The review does not provide specific experimental data or sample sizes, focusing instead on summarizing existing literature.
Digital Object Identifier (DOI)
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