THE NEUTROPHIL-LYMPHOCYTE RATIO AND WHITE BLOOD CELL COUNT ASSOCIATE WITH MUSCLE ENERGETICS AND GAIT SPEED IN SOMMA
2024
Inflammation, Muscle Energetics, and Gait Speed in Older Adults
Sample size: 945
publication
Evidence: moderate
Author Information
Author(s): Philip Kramer, Peggy Cawthon, Li-Yung Lui, Theodore DeConne, Nancy Lane, Xiaoyan Leng, Anne Newman, Stephen Kritchevsky
Primary Institution: Wake Forest University School of Medicine
Hypothesis
How do systemic inflammation markers relate to muscle energetics and gait speed in older adults?
Conclusion
Systemic inflammation is linked to lower muscle energetics and slower gait speed in older adults.
Supporting Evidence
- Higher neutrophil-lymphocyte ratios are associated with lower muscle mitochondrial energetics.
- Individuals with higher NLR also have slower gait speeds.
- The study included a large sample size of adults aged 30-94.
Takeaway
Older people with higher inflammation levels tend to have weaker muscles and walk slower.
Methodology
Analysis of pro-inflammatory biomarkers in adults aged 30-94 from the Study of Muscle, Mobility and Aging (SOMMA).
Participant Demographics
Adults aged 30-94, with specific age groups of 30-69 (n=81) and 70-79 (n=864).
Statistical Information
P-Value
p=0.0002
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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