Increased Atherosclerosis in Mice Lacking Perilipin1
Author Information
Author(s): Langlois Dominique, Forcheron Fabien, Li Jacques-Yuan, del Carmine Peggy, Neggazi Samia, Beylot Michel
Primary Institution: University C Bernard Lyon
Hypothesis
The study investigates the role of perilipin1 in the development of atherosclerosis.
Conclusion
Mice without perilipin1 show increased atherosclerosis despite normal blood pressure and lipid levels.
Supporting Evidence
- Plin1-/- Ldlr-/- mice had a lower body weight and decreased adiposity.
- The atherosclerotic lesion area in Plin1-/- Ldlr-/- mice was significantly higher after 20 weeks of atherogenic diet.
- Histological examination showed no increased inflammation in Plin1-/- Ldlr-/- mice.
Takeaway
Mice that don't have a protein called perilipin1 get more heart problems, even though their blood pressure and fat levels are normal.
Methodology
Mice deficient in perilipin1 were crossed with Ldlr-/- mice and fed an atherogenic diet for 10 or 20 weeks to assess atherosclerosis development.
Limitations
The study used a global invalidation of perilipin1, making it difficult to determine the specific roles of different cell types.
Participant Demographics
Male mice were used in the experiments.
Statistical Information
P-Value
p < 0.01
Statistical Significance
p < 0.01
Digital Object Identifier (DOI)
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