Comparing Malaria Infection Susceptibility in Mosquitoes
Author Information
Author(s): Ndiath Mamadou O, Cohuet Anna, Gaye Ablaye, Konate Lassana, Mazenot Catherine, Faye Ousmane, Boudin Christian, Sokhna Cheikh, Trape Jean-François
Primary Institution: Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), IRD, Dakar, Sénégal
Hypothesis
The study aims to compare the susceptibility of M and S molecular forms of Anopheles gambiae and Anopheles arabiensis to infection by Plasmodium falciparum.
Conclusion
The molecular form S of An. gambiae is more susceptible to infection by P. falciparum than the molecular form M and An. arabiensis.
Supporting Evidence
- The oocyst rate was significantly higher in the molecular S form (79.07%) than in the M form (57.81%).
- Mean number of oocysts was greater in the An. gambiae S form (1.72) than in the An. gambiae M form (0.64).
- Sporozoite rate was also higher in the molecular form S (83.52%) than in form M (50.98%).
Takeaway
Some mosquitoes get sick from malaria more easily than others. This study found that one type of mosquito gets sick more often than another type.
Methodology
F3 progenies of Anopheles gambiae were infected with P. falciparum using direct membrane feeding, and infection was assessed by microscopy and ELISA.
Potential Biases
The tested mosquitoes were bred in the lab, which may not reflect the natural susceptibility of wild populations.
Limitations
The study was conducted in controlled laboratory conditions, which may not fully represent field populations.
Participant Demographics
Mosquitoes were collected from various breeding sites in Senegal.
Statistical Information
P-Value
p < 0.0001
Statistical Significance
p < 0.001
Digital Object Identifier (DOI)
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