MicroRNA Expression Profiles in Normal Human Tissues
Author Information
Author(s): Liang Yu, Dana Ridzon, Linda Wong, Caifu Chen
Primary Institution: Applied Biosystems, Foster City, CA, USA
Hypothesis
Measuring the quantity of miRNAs in normal human tissues provides essential baseline references to analyze the variation of miRNA abundance.
Conclusion
The study presents a global view of tissue distribution of miRNAs and their chromosomal locations, supporting their tissue-specific functional roles.
Supporting Evidence
- The study identified 345 miRNAs expressed in 40 normal human tissues.
- Hierarchical clustering of tissues based on miRNA expression profiles followed anatomical locations and physiological functions.
- Many miRNAs with co-regulated expression patterns are located within the same genomic clusters.
Takeaway
This study looked at tiny molecules called miRNAs in different human tissues to see how they work and where they are found.
Methodology
The study used TaqMan® MicroRNA Assays to quantify miRNA expression in 40 normal human tissues.
Limitations
The study did not have replicate samples for most tissue types, limiting the ability to identify tissue-specific miRNA markers.
Statistical Information
P-Value
0.0013 for placenta and 4 × 10-71 for PBMC
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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