The Role of BCCIP in Mouse Embryonic Development and Chromosome Stability
Author Information
Author(s): Lu Huimei, Huang Yi-Yuan, Mehrotra Sonam, Droz-Rosario Roberto, Liu Jingmei, Bhaumik Mantu, White Eileen, Shen Zhiyuan
Primary Institution: The Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey
Hypothesis
BCCIP is essential for maintaining genomic integrity during mouse embryonic development.
Conclusion
BCCIP deficiency leads to embryonic lethality and significant chromosome instability in mice.
Supporting Evidence
- BCCIP knockdown embryos displayed impaired cellular proliferation and increased apoptosis.
- BCCIP deficiency caused excessive spontaneous chromatin bridges and chromosome structural alterations.
- Deletion of the p53 gene did not rescue the embryonic lethality due to BCCIP deficiency.
Takeaway
BCCIP is a protein that helps embryos grow properly, and without it, the embryos can't develop and the chromosomes become unstable.
Methodology
The study used a conditional BCCIP knockdown transgenic mouse model to analyze the effects of BCCIP deficiency on embryonic development and chromosome stability.
Limitations
The study primarily focuses on mouse models, which may not fully represent human biology.
Digital Object Identifier (DOI)
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