Norepinephrine weaning in septic shock patients by closed loop control based on fuzzy logic

2008

Using Fuzzy Logic to Wean Norepinephrine in Septic Shock Patients

Sample size: 39 publication 10 minutes Evidence: moderate

Author Information

Author(s): Merouani Mehdi, Guignard Bruno, Vincent François, Borron Stephen W, Karoubi Philippe, Fosse Jean-Philippe, Cohen Yves, Clec'h Christophe, Vicaut Eric, Marbeuf-Gueye Carole, Lapostolle Frederic, Adnet Frederic

Primary Institution: Université Paris 13, Hôpital Avicenne

Hypothesis

Can closed-loop control based on fuzzy logic reduce the duration of norepinephrine weaning in septic shock patients?

Conclusion

The study found that fuzzy logic control significantly reduced the duration of norepinephrine weaning in septic patients.

Supporting Evidence

All patients in the fuzzy group successfully weaned off norepinephrine compared to 18 out of 20 in the control group.
The median duration of shock was significantly shorter in the fuzzy group.
The total amount of norepinephrine infused was significantly lower in the fuzzy group.
Mortality rates at 28 days were similar between both groups.

Takeaway

Doctors used a smart computer system to help patients get off a medicine called norepinephrine faster, which is used when they are very sick. This new method worked better than the old way.

Methodology

Patients were randomly assigned to receive norepinephrine either at the clinician's discretion or through a closed-loop control system based on fuzzy logic.