Fermented Wheat Germ Extract: Nutritional Supplement or Anticancer Drug?
Author Information
Author(s): Thomas Mueller, Wieland Voigt
Primary Institution: University of Halle, Department of Internal Medicine, Oncology/Hematology and Hemostaseology
Hypothesis
Can fermented wheat germ extract (FWGE) serve as an effective treatment for cancer patients?
Conclusion
The data suggest that FWGE may be a beneficial non-prescription supplement for cancer patients, but further large-scale studies are needed.
Supporting Evidence
- FWGE improved progression-free survival and overall survival in melanoma patients when combined with dacarbazine.
- In colorectal cancer studies, FWGE treatment showed favorable outcomes.
- FWGE was well tolerated with minimal side effects reported in clinical trials.
Takeaway
Fermented wheat germ extract might help cancer patients feel better and live longer, but more research is needed to be sure.
Methodology
The review summarizes preclinical and clinical data on the effects of FWGE in cancer treatment.
Potential Biases
The allocation design in some studies led to imbalances in patient characteristics.
Limitations
Most studies were not randomized and did not meet the standards for drug registration.
Participant Demographics
Patients included those with melanoma and colorectal cancer, with varying stages of disease.
Statistical Information
P-Value
<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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