Herbal Molecule PDBD Shows Promise in Treating Breast Cancer
Author Information
Author(s): Koduru Srinivas, Sowmyalakshmi Srinivasan, Kumar Raj, Gomathinayagam Rohini, Rohr Jürgen, Damodaran Chendil
Primary Institution: University of Kentucky
Hypothesis
Does the herbal molecule PDBD have a therapeutic effect on breast cancer cells?
Conclusion
PDBD may have wide therapeutic application in the treatment of breast cancer by selectively inducing apoptosis in cancer cells without harming normal cells.
Supporting Evidence
- PDBD inhibits cell viability of both ER+ and ER- breast cancer cells.
- PDBD induces apoptosis in breast cancer cells without significant toxicity to normal cells.
- PDBD downregulates pro-survival proteins like Bcl-2 and XIAP.
- PDBD activates pro-apoptotic signaling pathways in breast cancer cells.
Takeaway
A natural compound called PDBD can help fight breast cancer by making cancer cells die while leaving healthy cells alone.
Methodology
Breast cancer cell lines were treated with PDBD, and various assays were performed to assess cell viability, apoptosis, and signaling pathways.
Limitations
The study primarily focuses on in vitro results, and further in vivo studies are needed to confirm the findings.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website