Treg Control of Cytokine Storm in CD28 Superagonist Treated Mice
Author Information
Author(s): Gogishvili Tea, Langenhorst Daniela, Lühder Fred, Elias Fernando, Elflein Karin, Dennehy Kevin M., Gold Ralf, Hünig Thomas
Primary Institution: Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany
Hypothesis
Can regulatory T-cells (Treg) prevent cytokine storms induced by CD28 superagonist treatment?
Conclusion
The study found that Treg cells effectively suppress the inflammatory response and prevent cytokine storms in mice treated with CD28 superagonists.
Supporting Evidence
- Treg cells were shown to expand significantly after CD28 superagonist treatment.
- Depletion of Treg cells led to systemic release of pro-inflammatory cytokines.
- High-dose dexamethasone did not affect Treg cell activation.
Takeaway
This study shows that special immune cells called Treg can stop a dangerous reaction in mice when given a specific treatment.
Methodology
Mice were treated with a CD28 superagonist and analyzed for Treg cell expansion and cytokine levels.
Limitations
The study was conducted in mice, which may not fully predict human responses.
Participant Demographics
C57BL/6 mice, 6-10 weeks old.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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